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I. East West Essential's Optimal Folate Blend

We have had concerns about the folic acid some of our patients are taking not being properly assimilated (absorbed) by their bodies! Optimal Folate Blend provides our patients with pre-"broken down" Folate to enhance Folate metabalism. Whether dealing with elevated homocystein levels, recurrent miscarriage, or a familial risk for neural tube defects or looking to prevent these issues, we feel that it is essential that our patients are provided with a folic acid that gives them the best possibility assimilation of Folate.

II. Benefits Common to most Folic Acids

Encourages prenatal health
Promotes cardiovascular health
Promotes nervous system and mental function
Promotes detoxification
Promotes breast health
Promotes maintenance of DNA

III. East West Essential's Optimal Folate Blend: Why it is unique

1. It is well accepted that folic acid supplementation should be given preconception to reduce of the risk of neural tube defects. Optimal Folate Blend uses patented, body ready forms of folic acid to increase folic acid bioavailability. The first step to folic acid metabolism is bypassed by providing it in this more advanced form. This is critical for patients with a history of reoccurring pregnancy loss and/or a familial history of neural tube defects. Optimal Folate Blend has added three forms of folic acid in their proprietary blend. This all-inclusive, bio-available blend encourages methylation pathways at various points of folate metabolism, which may better support overall methylation than a single form of folate especially in those patients with genetic variations in folate metabolism. These nutrients are essential to provide the precursor for DNA synthesis and erythrocyte formation. Therefore, Optimal Folate Blend has added 800 mcg of these superior forms of folic acid critical for people whose folate status may be affected thus reducing the risk for miscarriage and/or neural tube defects.

2. In addition, Optimal Folate Blend supplies high levels of vitamin B12, a crucial nutrient conversion of homocysteine to methionine. A deficiency of B12 and/or THF is known to block the methylation pathways for the proper synthesis of DNA and, therefore, the growth and function of all cells in the body. This can also result in elevated homocysteine levels in the patient.

3. Optimal Folate Blend features intrinsic factor, a natural glycoprotein that is necessary for the absorption of vitamin B12. A lack of intrinsic factor in gastric secretions (a substance needed to absorb vitamin B12 from the gastrointestinal tract) can result in B12 deficiency, slowing the methylation process and can cause a pooling of homocysteine. Megaloblastic (pernicious) anemia is a severe example of this and folic acid and B12 supplementation are at times effective treatments.

SUPPLEMENT FACTS Serving size 1 Tablet Servings per container 30	amount per serving	% DV
Folate (as folic acid, L-5 methyl tetrahydrofolate++,5-formyl tetrahydrofolate)	800 mcg	200%
Vitamin B12(as cyanocobalamin)	500 mcg	8333%
Calcium	90 mg	9%
Phosphorus	69 mg	7%
Intrinsic Factor	20 mg	**

Other ingredients: Dicalcium phosphate, stearic acid, cellulose, and magnesium stearate.

IV. East West Essential's Optimal Folate sited research

1. Superior Form of Folic Acid
JNEPHROL 2000; 13: 20-33

2. Added B12 aids in Folic acid metabolism
Dietary Supplement Fact Sheet: Vitamin B12

Office of Dietary Supplements NIH Clinical Center National Institutes of Health

3. Added Intrinsic factor, a glycoprotein that enhances the absorption of vitamin B12.
J. American Academy of Family Physicians, March 2, 2003

V. East West Essential's Optimal Folate Blend Ingredients and their relationship to fertility

1. VitaminB12 (cyanocobalamin) (Anemia, Homocysteine, Male infertility, Preeclampsia, Neural-tube defects)

2. Folate (Homocysteine, Neural-tube, preeclampsia, Male infertility, Anemia)

3. Intrinsic Factor (a natural glycoprotein that may enhance the absorption of vitamin B12.)